Exploring the Pharmacological Properties of Dextroamphetamine
Exploring the Pharmacological Properties of Dextroamphetamine


Dextroamphetamine is a potent central nervous system (CNS) stimulant belonging to the amphetamine class of psychoactive drugs. It is widely prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy due to its ability to enhance alertness, focus, and cognitive function.

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Chemical Properties:

  • Chemical Formula: C9H13N
  • Molar Mass: 135.21 g/mol
  • Appearance: Typically white crystalline powder
  • Melting Point: Approximately 172-175°C
  • Solubility: Soluble in water and polar organic solvents

Mechanism of Action:

Dextroamphetamine acts primarily by increasing the synaptic concentrations of dopamine and norepinephrine in the brain. It achieves this by promoting the release of these neurotransmitters from presynaptic neurons and inhibiting their reuptake, thereby prolonging their effects on postsynaptic receptors.

Therapeutic Uses:

  • ADHD Treatment: Dextroamphetamine and its formulations, such as Adderall, are widely prescribed for the management of ADHD symptoms in children and adults. They help improve attention span, impulse control, and behavioral regulation.
  • Narcolepsy Management: Dextroamphetamine is also indicated for the treatment of narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and sudden onset of sleep attacks. It helps promote wakefulness and reduce episodes of sleepiness and cataplexy.

Adverse Effects:

Despite its therapeutic benefits, dextroamphetamine is associated with several potential side effects, including insomnia, loss of appetite, weight loss, dry mouth, headache, irritability, and increased heart rate. Long-term use may lead to tolerance, dependence, and withdrawal symptoms upon discontinuation.


Dextroamphetamine is a valuable medication for the treatment of ADHD and narcolepsy, offering significant benefits in improving cognitive function and reducing daytime sleepiness. However, its potential for abuse and adverse effects necessitates cautious prescribing practices and regular monitoring by healthcare professionals. Further research is needed to elucidate its long-term safety profile and optimize its therapeutic use.

Information for preparing this article was taken from the site: https://www.webmd.com/drugs/2/drug-1636-7080/dextroamphetamine-oral/dextroamphetamine-sustained-action-capsule-oral/details

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